1. The first identified mechanisms of steroid hormone action were the genomic effects. 2. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones . 3. It is also the basic building block of steroid hormones , including neurosteroids. 4. P52SHC and p66SHC have been found in steroid hormone -regulated cancer and metastasizes. 5. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism. 6. Cholesterol is a precursor of many essential steroid hormones such as progesterone. 7. In ovarian cancers, DLC-1 expression is upregulated by the steroid hormone progesterone. 8. Steroid hormone metabolism modulators " List of androgens / anabolic steroids"9. Steroid hormones control many aspects of reproduction, development, and homeostasis in higher organisms.10. Nuclear receptors that bind steroid hormones are all classified as type I receptors.